Risk of Urinary Bladder Tumours in Firemen

Evaluation of the prognostic value of CD117 and CK20 biomarkers in urinary bladder carcinoma

Background: Over-expression of CD117 and cytokeratin 20 (CK20) is seen in many malignancies. Given that few studies have been conducted regarding the role of these biomarkers in the etiology of bladder tumours, this study aimed to evaluate the prognostic value of CD117 and CK 20 biomarkers in the benign and malignant tumours of urinary bladder carcinoma. Methods: This case-control study was co...

Computer-based grading of haematoxylin-eosin stained tissue sections of urinary bladder carcinomas.

PURPOSE A computer-based image analysis system was developed for assessing the malignancy of urinary bladder carcinomas in a more objective manner. Tumours characterized in accordance with the WHO grading system were classified into low-risk (grades I and II) and high-risk (grades III and IV). MATERIALS AND METHODS Images from 92 haematoxylin-eosin stained sections of urinary bladder carcinom...

Risk of Kidney Tumours in Firemen

Risk of Brain Tumours in Firemen

Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers

BACKGROUND Colorectal, endometrial and upper urinary tract tumours are characteristic for Lynch syndrome (hereditary non-polyposis colon carcinoma, HNPCC). The aim of the present study was to establish whether carriers of mutations in mismatch repair genes MLH1, MSH2 or MSH6 are at increased risk of urinary bladder cancer. METHODS Carriers and first degree relatives of 95 families with a germ...